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Ganglion-blocking activity of bisquaternary ammonium salts derived from 3α,12α-diamino-5β-cholane and 3α,12α-diamino-24-nor-5β-cholane

✍ Scribed by I.G. Marshall; M. Martin-Smith

Book ID
118321095
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
387 KB
Volume
17
Category
Article
ISSN
0014-2999

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✍ Dieter Verzele; Annemieke Madder 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 128 KB 👁 1 views

## Abstract A short, practical, multigram‐scale synthesis of C3α‐NHAlloc, C12α‐NHBoc‐diamino‐5β‐cholan‐24‐oic acid **2** was developed, applying a new, straightforward synthetic strategy. Key features are the conservation of the carboxyl moiety at C24 during oxime reduction, the late differentiatio