𝔖 Bobbio Scriptorium
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Gammaherpesviruses encode functional dihydrofolate reductase activity

✍ Scribed by Gábor Gáspár; Erik De Clercq; Johan Neyts

Book ID
117052628
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
74 KB
Volume
297
Category
Article
ISSN
0006-291X

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The mechanism responsible for the toxic late effects of cranial irradiation, followed by the administration of systemic methotrexate (MTX) on brain tissue, is still under discussion. We studied the influence of X-irradiation on dihydrofolate reductase (E.C. 1.5.1.3) activity (DHFR), the enzyme inhib