Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
✍ Scribed by Na Lu; Yong Yang; Qi-Dong You; Yun Ling; Ying Gao; Hong-Yan Gu; Li Zhao; Xiao-Tang Wang; Qing-Long Guo
- Book ID
- 116334518
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 736 KB
- Volume
- 258
- Category
- Article
- ISSN
- 0304-3835
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Emodin (1,3,8‐trihydroxy‐6‐methylanthraquinone), an active component in the root and rhizome of __Rheum palmatum__, is a tyrosine kinase inhibitor with a number of biological activities, including antitumor effects. Here, we examine the effects of emodin on vascular endothelial growth f
Vascular endothelial growth factor (VEGF), which is one of the most potent angiogenic factors, has been shown to play a pivotal role in tumor angiogenesis, including hepatocellular carcinoma (HCC). The effects of VEGF are mediated mainly through two distinct receptors, flt-1 and KDR/ Flk-1. It has b
## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production