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Galvanotaxis of human granulocytes

✍ Scribed by B. Rapp; A. Boisfleury-Chevance; H. Gruler

Publisher: Springer
Year: 1988
Tongue: English
Weight: 663 KB
Volume: 16
Category: Article
ISSN: 1432-1017
DOI: 10.1007/bf00254068

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✦ Synopsis

The galvanotactic response of human granulocytes was investigated theoretically and experimentally. The basic results are: (i) The granulocytes move towards the anode. (ii) The directed movement has been quantified by two different polar order parameters--the McCutcheon index and the average of cos phi. (iii) The polar order parameters are a function of the applied electric field (= dose-response curve). (iv) The inverse of the galvanotactic constant of migrating cells (analogous to the Michaelis-Menten constant) has a value of -0.2 +/- 0.03 V/mm. (v) The galvanotactic response of granulocytes is a non-cooperative process with a cooperativity coefficient of 1 +/- 0.2. (vi) The galvanotactic constant is a function of pH. (vii) The protein essential for the galvanotactic response is very likely a G-protein.

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