The secretory compartment for biliary lecithin and cholesterol secretion probably resides in the smooth endoplasmic reticulum of the hepatocyte. The secretory compartment for bile salts lies predominantly in the enterohepatic circulation which fluxes bile salts continuously through the smooth endopl
Gallstone prevalence and biliary lipid composition in inflammatory bowel disease
โ Scribed by Marks, J. W. ;Conley, D. R. ;Capretta, T. L. ;Bonorris, G. G. ;Chung, A. ;Coyne, M. J. ;Schoenfield, L. J.
- Book ID
- 112476060
- Publisher
- Springer-Verlag
- Year
- 1977
- Weight
- 357 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0002-9211
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## Background: The incidence of inflammatory bowel disease (IBD) may be lower among people of African descent than Caucasians. However, incidence studies among the former are uncommon and are often limited by incomplete case ascertainment or uncertainty about the size of the "at-risk" population.
In five patients with radiolucent gallstones, the effect of ursodeoxycholic acid (Urso) in doses of 250,500, 750, 1,000, and 1,250 mg per day on biliary lipid and bile acid composition was studied. Biliary cholesterol decreased from 8.8 f 0.8 mole% to 4.4 f 0.2 mole% at 500 mg Urso per day (7.1 mg p