## Abstract Myelin basic protein (MBP) is one of the major components of the myelin sheath that insulates axons. In the central nervous system, MBP is synthesized by differentiating oligodendrocytes. The expression of MBP in oligodendrocytes is regulated mainly at the transcriptional level. The Sp1
β¦ LIBER β¦
Galectin-4 is involved in p27-mediated activation of the myelin basic protein promoter
β Scribed by Qiou Wei; Tamar Eviatar-Ribak; W. Keith Miskimins; Robin Miskimins
- Book ID
- 111180128
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 649 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0022-3042
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## Abstract In vivo and in vitro studies have shown that Ξ±βaminoβ3βhydroxyβ5βmethylisoxazoleβ4βpropionic acid (AMPA)βreceptorβmediated excitotoxicity causes cytoskeletal damage to axons. AMPA/kainate receptors are present on oligodendrocytes and myelin, but currently there is no evidence to suggest