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Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin

✍ Scribed by Sanchez-Ruderisch, H; Detjen, K M; Welzel, M; André, S; Fischer, C; Gabius, H-J; Rosewicz, S

Book ID
109842371
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
1005 KB
Volume
18
Category
Article
ISSN
1350-9047

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Cytofluorimetric and reverse-transcription polymerase chain reaction (RT-PCR) analysis showed that adriamycinresistant (ADR R ), but not sensitive (WT), MCF-7 human mammary carcinoma cell lines express a4b1 and a5b1 integrins. ADR R cells adhere to fibronectin (FN), and only a5b1 is involved in cell