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Galectin-1 expression in innervated and denervated skeletal muscle

✍ Scribed by Anna Svensson; Sven Tågerud

Book ID
111490446
Publisher
SP Versita
Year
2009
Tongue
English
Weight
689 KB
Volume
14
Category
Article
ISSN
1425-8153

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✦ Synopsis

Abstract

Galectin-1 is a soluble carbohydrate-binding protein with a particularly high expression in skeletal muscle. Galectin-1 has been implicated in skeletal muscle development and in adult muscle regeneration, but also in the degeneration of neuronal processes and/or in peripheral nerve regeneration. Exogenously supplied oxidized galectin-1, which lacks carbohydrate-binding properties, has been shown to promote neurite outgrowth after sciatic nerve sectioning. In this study, we compared the expression of galectin-1 mRNA and immunoreactivity in innervated and denervated mouse and rat hind-limb and hemidiaphragm muscles. The results show that galectin-1 mRNA expression and immunoreactivity are up-regulated following denervation. The galectin-1 mRNA is expressed in the extrasynaptic and perisynaptic regions of the muscle, and its immunoreactivity can be detected in both regions by Western blot analysis. The results are compatible with a role for galectin-1 in facilitating reinnervation of denervated skeletal muscle.

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## Abstract Plasminogen activators (urokinase‐type, u‐PA and tissue‐type, t‐PA) are serine proteases that have been suggested to play important roles in synaptic remodeling. The enzymatic activity of u‐PA in particular has previously been shown to increase dramatically after denervation of skeletal