Galanin plasticity in the cholinergic basal forebrain in Alzheimer’s disease and transgenic mice
✍ Scribed by Elliott J. Mufson; Scott E. Counts; Sylvia E. Perez; L. Binder
- Book ID
- 113824290
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 311 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0143-4179
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The concept that galanin (GAL) is cosecreted with acetylcholine (ACh) into the ventral hippocampus is a major component of the current model delineating GAL regulation of the cholinergic memory pathways in the rat. Although GAL-immunoreactivity coexists in 50-70% of cholinergic neurons in the basal
Previous studies have indicated that galanin is one of the most abundant peptides in the basal forebrain and that it has a significant modulatory influence on cholinergic transmission. The aim of the present study was to use a light electron microscopic correlation technique to determine whether gal