NAD+ as a metabolic link between DNA dam
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Weihai Ying; Conrad C. Alano; Philippe Garnier; Raymond A. Swanson
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Article
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2004
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John Wiley and Sons
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English
β 251 KB
## Abstract DNA damage occurs in ischemia, excitotoxicity, inflammation, and other disorders that affect the central nervous system (CNS). Extensive DNA damage triggers cell death and in the mature CNS, this occurs primarily through activation of the poly(ADPβribose) polymeraseβ1 (PARPβ1) cell deat