## Abstract Overexpression of cyclooxygenaseβ2 (COXβ2) and elevation of its derivative prostaglandin E~2~ (PGE~2~) are implicated in human esophageal squamous cell carcinoma. The expression of cβMyc, an oncogenic transcription factor, is also upregulated in this malignant disease. This study sought
β¦ LIBER β¦
Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors
β Scribed by Kanazawa, T; Iwashita, T; Kommareddi, P; Nair, T; Misawa, K; Misawa, Y; Ueda, Y; Tono, T; Carey, T E
- Book ID
- 110072382
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 485 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0950-9232
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Although the cytokine-inducible transcription factor signal transducer and activator of transcription 5 (STAT5) promotes proliferation of a wide range of cell types, there are cell-specific and context-specific cases in which loss of STAT5 results in enhanced cell proliferation. Here, we report that