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Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells

✍ Scribed by Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Rosaria M. Pipitone; Luisa Dusonchet; Maria Meli; Lucia Crosta; Nicola Gebbia; Francesco Paolo Invidiata; Lucina Titone; Daniele Simoni


Book ID
116334699
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
421 KB
Volume
265
Category
Article
ISSN
0304-3835

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## Abstract The Bcr‐Abl inhibitor imatinib is the current first‐line therapy for all newly diagnosed chronic myeloid leukemia (CML). Nevertheless, resistance to imatinib emerges as CML progresses to an acute deadly phase implying that physiopathologically relevant cellular targets should be validat