Different protective groups for (5R)-5-hydroxy-l-lysine were investigated in silver silicate promoted glycosylations with acetobromogalactose as glycosyl donor. Best results were obtained with Fmoc-Hyl(Cbz)-OAll, which was glycosylated in 80% yield. Removal of the allyl group gave a b-d-galactosylat
✦ LIBER ✦
Galactosylated 5-Hydroxylysine Mimetics for Glycopeptide Synthesis
✍ Scribed by Julien Marin; Aude Violette; Jean-Paul Briand; Gilles Guichard
- Book ID
- 102175629
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 264 KB
- Volume
- 2004
- Category
- Article
- ISSN
- 1434-193X
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## Abstract An analogue of the immunodominant glycopeptide from type II collagen encompassing residues 256–270 has been prepared by substituting β‐D‐galactopyranosyl‐(2__S__,4__R__)‐4‐hydroxy‐L‐lysyl (Gal‐4‐Hyl) for β‐D‐galactopyranosyl‐(2__S__,5__R__)‐5‐hydroxy‐L‐lysyl (Gal‐5‐Hyl) at position 264.
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