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Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG

✍ Scribed by Tomana, Milan; Matousovic, Karel; Julian, Bruce A; Radl, Jiri; Konecny, Karel; Mestecky, Jiri

Book ID
109884911
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
850 KB
Volume
52
Category
Article
ISSN
0085-2538

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The mechanism of mesangial IgA deposition is poorly understood in IgA nephropathy (IgAN). Abnormal glycosylation of carbohydrate moieties in the hinge region of the IgA molecule has recently attracted much attention. In this report, we studied galactosylation and sialylation profiles in ΞΊand Ξ»-IgA 1