Gaining fluid bed process understanding by in-line particle size analysis

✍ Scribed by Tero Närvänen; Tanja Lipsanen; Osmo Antikainen; Heikki Räikkönen; Jyrki Heinämäki; Jouko Yliruusi

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 150 KB
• Volume: 98
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.21486

✦ Synopsis

Different process phenomena and process failure modes could be monitored using the in-line particle size data measured by spatial filtering technique (SFT). In addition to the real-time granule growth monitoring, other events, such as the blocking of filter bags and the distributor plate, could be observed. SFT was used offline, at-line and in-line in 14 differently manufactured granulation batches. No significant fouling occurred during the manufacturing due to the appropriate positioning of the probe. The off-line SFT results correlated well (R 2 ¼ 0.97) with the sieve analysis results. It was also found that size segregation influenced both the in-line and at-line particle size results during the fluidization: in-line method underestimated and at-line method overestimated the final particle size.