Gain of chromosome 7 detected by comparative genomic hybridization accumulates with age in patients with glioblastoma multiforme
β Scribed by Margit A Zuber; Ronald Koschny; Thomas Koschny; Ursula G Froster
- Book ID
- 114135318
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 144 KB
- Volume
- 136
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Comparative genomic hybridization (CGH) has been widely used to detect copy number alterations in cancer and to identify regions containing candidate tumorβresponsible genes; however, gene expression changes have been described only in highly amplified regions (amplicons). To study the
## Procedure. To establish the significance of chromosome 17 aberrations in the biology of neuroblastomas, the fresh-frozen material of 53 primary neuroblastomas (average patient age: 20.8 months; stage 1 or 2: n = 10; stage 3: n = 10; stage 4: n = 10; stage 4s: n = 23) was studied by means of com