Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha
β Scribed by Lei, G.
- Book ID
- 111749413
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 483 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0261-4189
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Modulation of N-methyl-D-aspartate (NMDA) receptor-mediated ion currents by serotonin was investigated with a two-electrode voltage clamp technique in Xenopus oocytes injected with rat brain RNA. After a 1-min application of 200 nM serotonin a transient potentiation of the NMDA receptor-mediated ion
## Abstract Lowβlevel activation of __N__βmethylβdβaspartate receptors (NMDARs) results in a decrease in the ability of tetanic stimulation to induce longβterm potentiation (LTP). This NMDARβmediated LTP inhibition is observed with low micromolar concentrations of NMDA or chelation of ambient extra