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GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells

✍ Scribed by Binfeng Lu; Hong Yu; Chi-wing Chow; Baiyong Li; Wei-ping Zheng; Roger J Davis; Richard A Flavell

Book ID
117723055
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
303 KB
Volume
14
Category
Article
ISSN
1074-7613

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Mitogen-activated protein (MAP) kinases have been implicated as important mediators of the inflammatory response. Here we report that c-Jun NH(2)-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 MAP kinase activities are reprogrammed during the IL-6 induced macrophage-like