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Gabosines L, N and O: New Carba-Sugars from Streptomyces with DNA-Binding Properties

✍ Scribed by Yuan-Qing Tang; Corinna Maul; Regina Höfs; Isabel Sattler; Susanne Grabley; Xiao-Zhang Feng; Axel Zeeck; Ralf Thiericke

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
260 KB
Volume
2000
Category
Article
ISSN
1434-193X

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✦ Synopsis

In addition to the known gabosines A (4), B (5) and C (6), stereochemistry of 1 and 2 was determined by Helmchen's method and has been verified in the case of gabosine N (2) three new gabosines L (1), N (2) and O (3) were detected by chemical screening as secondary metabolites of Strep-by X-ray analysis. The DNA-binding properties of the gabosines were investigated and analyzed by binding tomyces (strains GT 041230, GT 051024 and S 1096). The constitutions of 1, 2 and 3 were established by spectroscopic studies using a recently developed thin-layer chromatography technique (bimolecular-chemical screening). techniques and derivatization reactions. The absolute matography on Sephadex LH-20 (methanol) to yield

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ChemInform Abstract: Gabosines L, N, and
ChemInform Abstract: Gabosines L, N, and O: New Carba-Sugars from Streptomyces with DNA-Binding Properties.
✍ Yuan-Qing Tang; Corinna Maul; Regina Hoefs; Isabel Sattler; Susanne Grabley; Xia 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

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