Gabapentin suppresses cortical spreading
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Hoffmann, Ulrike; Dileköz, Ergin; Kudo, Chiho; Ayata, Cenk
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Article
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2010
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Nature Publishing Group
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English
⚖ 253 KB
Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca~v~2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca~v~2.1 through high-affinity binding to its α~2~δ subunit, on CSD