GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus

Detection of novelty, but not memory of

Detection of novelty, but not memory of spatial habituation, is associated with an increase in phosphorylated cAMP response element-binding protein levels in the hippocampus

✍ Milena Winograd; Haydée Viola 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB

## Abstract There is a growing body of evidence showing that the formation of associative memories is associated with an increase in phosphorylated cAMP response element‐binding protein (pCREB) levels. We recently reported increased pCREB levels in the rat hippocampus after an exploration to a nove