GABAB receptor antagonist and GABAA receptor agonist properties of a δ-aminovaleric acid derivative, Z-5-aminopent-2-enoic acid

Improved synthesis of (5Z)-7-(3-endo-{(b

Improved synthesis of (5Z)-7-(3-endo-{(benzenesulfonamido)-bicyclo[2.2.1]heptyl}hept-5-enoic acid (S-145) derivatives and their iodine-125-labeled radioligands for the study of thromboxane A2 receptor

✍ Wai Ming Kan; Hsin-Hsiung Tai 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 567 KB

An improved synthetic scheme for (5Z)-7-[3-endo-[(benzenesulfonamido)-bicyclo[2.2.1]heptyl I-hept-5-enoic acid (S145) and its analogs has been designed. The procedure involves direct sulfonylation of 2-allyl-3-aminobicyclo[2.2. l]heptane intermediate followed by ozonolysis and addition of a C5 carbo