GABA transminase provides an alternative route of β-alanine synthesis in Aspergillus nidulans

✍ Scribed by Arst, Herbert N.

• Book ID: 104693901
• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 415 KB
• Volume: 163
• Category: Article
• ISSN: 0026-8925
• DOI: 10.1007/bf00268960

✦ Synopsis

Three unlinked genes where mutation can lead to D(+)-pantothenic acid auxotrophy in Aspergillus nidulans have been identified. pantoA is probably the structural gene for pantothenate synthetase (EC 6.3.2.1) whilst pantoB and pantoC are involved in the syntheses of D-pantoic acid and beta-alanine, respectively. A pantoC- mutant is tentatively considered to be blocked in conversion of 5,6-dihydrouracil to beta-ureidopropionate. An alternative route of beta-alanine biosynthesis occurs by the transamination of malonic semialdehyde, catalysed by GABA transaminase. The possibility that beta-alanine can be replaced by certain structurally related compounds and yet nevertheless yield biologically active coenzyme A analogues is discussed.