GABA, progesterone and zona pellucida activation of PLA2 and regulation by MEK-ERK1/2 during acrosomal exocytosis in guinea pig spermatozoa

Progesterone primes zona pellucida-induc

Progesterone primes zona pellucida-induced activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa

✍ Qi-xian Shi; W.Y. Chen; Y.Y. Yuan; L.Z. Mao; S.Q. Yu; A.J. Chen; Y. Ni; E.R.S. R 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 164 KB

## Abstract We investigated, using guinea‐pig spermatozoa as a model, whether phospholipase A~2~ (PLA~2~) is involved in progesterone or zona pellucida (ZP)‐stimulated acrosomal exocytosis, if progesterone enhances ZP‐induced activation of PLA~2~, and mechanisms underlying PLA~2~ regulation. Sperma