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GABA and amino acid concentrations in lumbar CSF in patients with treated and untreated epilepsy

✍ Scribed by Pamela M. Crawford; David W. Chadwick

Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
878 KB
Volume
1
Category
Article
ISSN
0920-1211

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✦ Synopsis

Lumbar free CSF GABA and amino acid concentrations were measured in 43 patients with newly diagnosed untreated epilepsy and 26 patients with chronic drug-resistant epilepsy. The results were compared with those from 51 control patients. No differences in free CSF GABA concentration could be detected between patients with epilepsy, either treated or untreated, and controls. Untreated patients with primary generalised epilepsy and partial seizures had similar free CSF GABA concentrations. These results would not support the hypothesis that patients with epilepsy have a global disturbance of GABA function. CSF taurine, asparagine, aspartate, glycine and alanine were significantly reduced in patients with epilepsy compared to the control population.

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