G-protein regulatory pathways: Rocketing into the twenty-first century
✍ Scribed by Cindy Knall; Gary L. Johnson
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 89 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0730-2312
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✦ Synopsis
Complex cellular responses involve the integration of heterotrimeric G protein systems with protein kinase signal transduction pathways. Key in this integration is the control of small GTP-binding proteins including Ras and Rho family members. In this paper, we discuss the control of signal transduction pathways by G proteins and their integration with specific tyrosine kinases. The integration of G proteins, kinases, and small GTP-binding proteins in controlling cellular responses is illustrated through the newly defined G␣ 12/13 -regulated pathways. Furthermore, the polymorphonuclear leukocyte provides a primary cell system for analyzing the integration of G proteins, kinases, and small GTP-binding proteins in controlling cellular functions such as superoxide production, adherence, chemotaxis, and granule secretion.