Allosteric ligands for G protein-coupled
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Marco De Amici; Clelia Dallanoce; Ulrike Holzgrabe; Christian TrΓ€nkle; Klaus Moh
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Article
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2009
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John Wiley and Sons
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English
β 865 KB
Allosteric receptor ligands bind to a recognition site that is distinct from the binding site of the endogenous messenger molecule. As a consequence, allosteric agents may attach to receptors that are already transmitter-bound. Ternary complex formation opens an avenue to qualitatively new drug acti