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G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery

โœ Scribed by Mark H. Pausch

Book ID
114152907
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
933 KB
Volume
15
Category
Article
ISSN
0167-7799

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The ability of high throughput membrane binding assays to detect ligands for G-protein coupled receptors was examined using mathematical models. Membrane assay models were developed using the extended ternary complex model (Samama et al., 1993) as a basis. Ligand binding to whole cells was modeled b