G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice
β Scribed by Gibson, Claire L; Bath, Philip M W; Murphy, Sean P
- Book ID
- 110046409
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 196 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0271-678X
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## Abstract Unfractionated heparin (UH) decreases the extent of infarction after transient focal brain ischemia in the rat and abridges neuroinflammatory damage in patients with acute stroke. This study was aimed at assessing whether controlled and steady heparinemia in plasma can reduce infarct vo
## Abstract Recent studies have shown that administration of granulocyte colonyβstimulating factor (GβCSF) is neuroprotective. However, the precise mechanisms of the neuroprotective effect of GβCSF are not entirely known. We carried out 90βmin transient middle cerebral occlusion (tMCAO) of rats. Th