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G-CSF: Its relationship to leukemia differentiation-inducing activity and other hemopoietic regulators

โœ Scribed by Malcolm A. S. Moore


Book ID
102882289
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
939 KB
Volume
113
Category
Article
ISSN
0021-9541

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โœฆ Synopsis


The murine myelomonocytic leukemia WEHI-3B exists as differentiationinducible (D+) and noninducible (D-) cell lines. Both lines produce a CSF species that stimulates exclusively the formation of neutrophil granulocyte colonies. This G-CSF copurifies with a mast cell growth factor but can be separated from M-and GM-CSF. NZB bone marrow is unresponsive to G-CSF stimulation. WEHI-3B D+ cells can be induced to terminal granulocyte


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