G-CSF enhanced granulocyte production in a child with severe neutropenia in the setting of fatal virus-associated hemophagocytic syndrome
✍ Scribed by Eiichi Azuma; Nobutada Tabata; Takeo Shibata; Yoshihiro Komada; Masahiro Ito; Minoru Sakurai; Shin-Ichiro Atsumi; Yoko Kawasaki; Masahiko Ishii
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 330 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
A 1Cyear-old boy with fatal varicella zoster virus-associated hemophagocytic syndrome (VAHS) was treated with recombinant human granulocyte colony-stimulating factor (G-CSF) based on the finding that the patient had severe neutropenia and possible bacterial superinfection. Support for the G-CSF therapy in VAHS is provided by the recent reports that G-CSF is relatively specific for the granulocyte lineage; it would not activate mature monocyte/macrophage/histiocyte lineage in VAHS, where the most striking morphologic feature is histiocytic hyperplasia with hemophagocytosis. He responded well to G-CSF with an elevation of neutrophil counts. There were no effects on other blood cells. The result indicates that G-CSF is useful to increase granulocyte production in severe neutropenia, even In the setting of fatal VAHS.