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G-2548A Polymorphism of the Leptin Gene Is Correlated with Extreme Obesity in Taiwanese Aborigines

✍ Scribed by Tsu-Nai Wang; Meng-Chuan Huang; Wen-Tsan Chang; Albert Min-Shan Ko; Eing-Mei Tsai; Chih-Shan Liu; Chien-Hung Lee; Ying-Chin Ko

Book ID
109968376
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
59 KB
Volume
14
Category
Article
ISSN
1930-7381

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## Abstract Leptin is overexpressed in human breast tumors and is produced by breast cancer cells in response to obesity‐related stimuli. The leptin promoter polymorphism Lep‐2548G/A can be associated with increased leptin secretion by adipocytes and elevated cancer risk. However, molecular mechani