FYN-dependent muscle–immune interaction after sciatic nerve injury
✍ Scribed by Huang Hanwei; Hui Zhao
- Book ID
- 102953828
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 609 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0148-639X
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## Abstract Myostatin, a member of the transforming growth factor‐β (TGF‐β) superfamily, has been identified as a negative regulator of skeletal muscle mass. To provide more data on the role of myostatin in denervation‐induced muscle atrophy, we examined the time‐dependent changes in myostatin mRNA
Two types of nerve lesions were performed at birth in rat extensor digitorum longus muscle: sciatic nerve transection (group A) and sciatic nerve crush allowing further reinnervation (group 6). Contractile responses were then studied at different times after the denervation (7, 14, 30, and 60 days)