The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib
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Fuzzy Rule-Based Models to Predict the Partition Coefficients of Nickel and Zinc in Aquifer Materials
โ Scribed by Senevirathna, D. G. M.; Achari, G.; King, F.
- Book ID
- 119998085
- Publisher
- American Society of Civil Engineers
- Year
- 2011
- Tongue
- English
- Weight
- 217 KB
- Volume
- 15
- Category
- Article
- ISSN
- 2153-5493
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This research produced statistically based, semimechanistic models describing partitioning of Cu and Zn in 40 soils from the United States, Canada, the United Kingdom (UK), The Netherlands, and Chile with widely varying characteristics. Two different types of models were constructed, partitioning mo