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FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a

โœ Scribed by Reiko Inagi; Toshio Miyata; Kenji Maeda; Satoshi Sugiyama; Akio Miyama; Izumi Nakashima


Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
216 KB
Volume
27
Category
Article
ISSN
0165-2478

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โœ C.H. Kuo; S.P. Plevyak; T. Biftu; W.H. Parsons; G.D. Berger ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 258 KB

The title compound and its Cdpivaloyloxy methyl (PGM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6. Subsequent radical deoxygcnation via the Barton-McCombie procedure. followed by dqnvtection, affarded the product 11