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Fusions of pyrido[4′,3′:4,5]thieno[2,3-d]pyrimidines with N-heterocyclic moieties

✍ Scribed by E. Kh. Ahmed; U. Sensfuss; W. D. Habicher

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 323 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360501

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✦ Synopsis

Abstract

Versatile 2‐thioxopyrimidine‐type building blocks ethyl 3‐(2‐ethoxy‐2‐oxoethyl)‐4‐oxo‐2‐thioxo‐1,2,3,4,5,6,7,8‐octahydropyrido[4′,3′:4,5]thieno[2,3‐d]pyrimidine‐7‐carboxylate (4) and ethyl 4‐oxo‐2‐thioxo‐1,2,3,4,5,6,7,8‐octahydropyrido[4′,3′:4,5]thieno[2,3‐d]pyrimidine‐7‐carboxylate (8) were synthesized from diethyl 2‐amino‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3,6‐dicarboxylate (1). Derivatives of linear and angular heterocyclic systems having the imidazole and 1,2,4‐triazole ring were obtained from the key intermediates 4 and 8, respectively.

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