Transforming growth factor-beta1 (TGF-beta1) is widely recognized for its multiple roles in development, cellular maintenance, and protection against injury. In the brain, TGF-beta1 upregulation in microglia/macrophages is a predominant response to lesion and during pathology. However, the precise f
Fusions of dendritic cells and C6 cells transfected with TGF-β1 antisense in treatment of intracranial gliomas
✍ Scribed by Gui-shan Jin; Fu-sheng Liu; Qi Chai; Jian-jao Wang; Jun-hua Li
- Book ID
- 107466867
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2007
- Tongue
- English
- Weight
- 719 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1000-9604
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In mouse C3H 10T1/2 cells, we previously reported that TGF-beta1 first delays and later potentiates EGF-induced DNA synthesis corresponding to an inhibition of EGF-induced cyclin D1 expression at t = 13 h. We report here that in accord with DNA synthesis kinetics, TGF-beta1 initially suppresses EGF-