Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal proliferation of transformed myofibroblasts, with a prominent inflammatory cell component, that can mimic other spindle cell processes such as nodular fasciitis, desmoid tumor, and gastrointestinal stromal tumor. Genetic analyses have re
Fusion of the ALK Gene to the Clathrin Heavy Chain Gene, CLTC, in Inflammatory Myofibroblastic Tumor
β Scribed by Julia A. Bridge; Masahiko Kanamori; Zhigui Ma; Diane Pickering; D. Ashley Hill; William Lydiatt; Man Yee Lui; Gisele W.B. Colleoni; Cristina R. Antonescu; Marc Ladanyi; Stephan W. Morris
- Book ID
- 117021198
- Publisher
- American Society for Investigative Pathology
- Year
- 2001
- Tongue
- English
- Weight
- 489 KB
- Volume
- 159
- Category
- Article
- ISSN
- 0002-9440
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## Abstract Inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic spindle cells and infiltrating inflammatory cells. Cytogenetic analyses have revealed that a subgroup of IMT, in particular among children and young adults, harbors clonal chromosomal rearrangements invol
The t(14;18)(q32;q21) translocation, involving the BCL2 gene and junctional segments (J H ) of the immunoglobulin heavy chain gene (IGH), constitutes the most common chromosomal translocation in non-Hodgkin's lymphoma of B-cell type. Although the breakpoints in BCL2 are largely clustered within the