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Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

✍ Scribed by Galili, Naomi; Davis, Richard J.; Fredericks, William J.; Mukhopadhyay, Sunil; Rauscher, Frank J.; Emanuel, Beverly S.; Rovera, Giovanni; Barr, Frederic G.

Book ID: 109918542
Publisher: Nature Publishing Group
Year: 1993
Tongue: English
Weight: 678 KB
Volume: 5
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng1193-230

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Alveolar rhabdomyosarcomas frequently exhibit specific translocations, resulting in the fusion of the FKHR gene at 13q 14 with either the PAX3 or PAX7 gene at 2q35 and I p36, respectively. Comparative genomic hybridization revealed amplification at 13q14 and lp36, suggesting amplification of the PAX