✦ LIBER ✦

Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers

✍ Scribed by Taihang Li; Ruiyan Han; Mingzhe Wang; Changbai Liu; Xiabin Jing; Yubin Huang

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 807 KB
Volume: 11
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201100147

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

PEG‐PLA copolymers with dumbbell‐ and Y‐shaped structures are prepared. They can self‐assemble from nanoparticles to micro‐sized fusiform micellar particles in aqueous solution. In particular the micelles formed by the (PLA)~2~‐PEG‐(PLA)~2~ particles show a better drug loading capacity and encapsulation efficiency than those formed by linear MPEG‐PLA. In vitro studies show that the particles formed by Y‐shaped copolymers show a particularly quick drug release. The copolymers have good biocompatibility with low cytotoxicity. These unique self‐assembled systems thus have many possible biomedical applications, such as a sustained delivery of high‐dosed water insoluble drugs, quick effective drugs for trauma, controlled delivery of the oral‐administration drugs, and so forth. magnified image

📜 SIMILAR VOLUMES

Biodegradable polylactide/poly(ethylene

Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers

✍ Li Liu; Chenxi Li; Xuechen Li; Zhi Yuan; Yingli An; Binglin He 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB

Biodegradable drug carriers based on pol

Biodegradable drug carriers based on poly(ethylene glycol) block copolymers

✍ Michal Pechar; Jiří Strohalm; Karel Ulbrich; Etienne Schacht 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 614 KB

## Abstract The synthesis of a model water‐soluble drug carrier system based on poly(ethylene glycol) (PEG) block copolymers is described. In the system, two blocks of PEG are connected via a biodegradable oligopeptide or amino acid linkage incorporating at least one glutamic acid residue. A drug m

Biodegradable nanoparticles of amphiphil

Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3-hydroxybutyrate) and poly(ethylene glycol) as drug carriers

✍ Cheng Chen; Chung Him Yu; Yin Chung Cheng; Peter H.F. Yu; Man Ken Cheung 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 320 KB

Preparation, characterization, and prope

Preparation, characterization, and properties of polylactide (PLA)–poly(ethylene glycol) (PEG) copolymers: A potential drug carrier

✍ K. J. Zhu; Lin Xiangzhou; Yang Shilin 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB 👁 2 views

Synthesis and Preliminary Biological Eva

Synthesis and Preliminary Biological Evaluation of Novel Functionalised Poly(ethylene glycol)-block-poly(ester-carbonate) Copolymers as Biodegradable Polymeric Carriers

✍ Veronica Vincenzi; Paolo Ferruti; Jayne Ford; Ruth Duncan 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB

Typical structure of polyester-polycarbonate synthesised. Scheme 1. Typical structure of polyester-polycarbonate synthesised.

In vitro cytotoxicity, hemolysis assay,

In vitro cytotoxicity, hemolysis assay, and biodegradation behavior of biodegradable poly(3-hydroxybutyrate)–poly(ethylene glycol)–poly(3-hydroxybutyrate) nanoparticles as potential drug carriers

✍ Cheng Chen; Yin Chung Cheng; Chung Him Yu; Shun Wan Chan; Man Ken Cheung; Peter 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 503 KB

## Abstract Nanoparticles based on amorphous poly(3‐hydroxybutyrate)–poly(ethylene glycol)–poly(3‐hydroxybutyrate) (PHB‐PEG‐PHB) are potential drug delivery vehicles, and so their cytotoxicity and hemolysis assay were investigated __in vitro__ using two kinds of animal cells. The PHB‐PEG‐PHB nanopa