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Further studies on the relationship of a rhabdomyosarcoma virus to muscle tissue

✍ Scribed by K. Perk; J. B. Moloney; E. G. Jenkins

Publisher
John Wiley and Sons
Year
1967
Tongue
French
Weight
870 KB
Volume
2
Category
Article
ISSN
0020-7136

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✦ Synopsis

The pathogenesis of a rhabdomyosarcoma virus isolate was studied in a total of 300 newborn BALBIc mice, I1 diffkrent routes of inoculation being used. The latent periods, or time in days to palpable tumor, varied over a wide range among the inoculated groups. The growth of the tumor was very rapid in the muscle tissue. Regardless of the route of inoculation, the neoplasms arose from the adjacent muscle tissue attaching to and prol$erating into the different organs and from their surfaces. Secondary tumor nodules were also observed in diferent areas of muscle tissue demonstrating the ufinity of this virus to muscle tissue. Exceptions were found in some of the intrasplenically and intramyocardially inoculated mice where primary tumor nodules were found within these organs. Histologically the tumor cells were less diferentiated toward myocytes than those described in a previous study.

It is suggested that this host response is a reflection of the high initiating virus dose employed.

Increase in spleen and liver weights and decrease in hematocrit values correlated closely to the extent of tumor development.

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