𝔖 Bobbio Scriptorium
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Further studies on the HIV proteinase inhibitor RO 31-8959

✍ Scribed by S. Galpin; J. Martin; T. O'Connor; S. Redshaw; N. Roberts; D. Kinchington


Book ID
118392569
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
68 KB
Volume
15
Category
Article
ISSN
0166-3542

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Conformational analysis of HIV protease
✍ Mark A. Murcko; B. Govinda Rao πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 719 KB

Pipecolic acid derivatives have proven to be effective Pi groups in a series of highly potent inhibitors of the enzyme HIV protease. One such inhibitor, Ro 31-8959, contains the saturated bicyclic ring system decahydroisoquinoline (DIQ) in the Pi position. The binding orientation of Ro 31-8959 is kn