Conformational analysis of HIV protease
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Mark A. Murcko; B. Govinda Rao
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Article
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1993
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John Wiley and Sons
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English
β 719 KB
Pipecolic acid derivatives have proven to be effective Pi groups in a series of highly potent inhibitors of the enzyme HIV protease. One such inhibitor, Ro 31-8959, contains the saturated bicyclic ring system decahydroisoquinoline (DIQ) in the Pi position. The binding orientation of Ro 31-8959 is kn