โ Scribed by Hammond, Phillip V.
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It has been demonstrated that cocaine will lessen some of the effects of ephedrine, chiefly cardiac out ut and blood pressure changes. The nature of the finer mechanism of action ofthese changes has not been ascertained. Because of the many unrelated sites of action it is believed there may possibly be more than one type of mechanism of action involved. Diminution of response to cocaine is largely cardiac in nature because vasoconstriction and increase in peripheral resistance in the femoral vascular bed was not marked. This action is chiefly central in origin because it cannot be demonstrated on the isolated rabbit heart. This indicates that the theory of Gaddum and Kwiatkowski (9) that the action of ephedrine is mediated chiefly through the presence of epinephrine cannot be demonstrated here, since cocaine will potentiate the action of epinephrine o n the isolated rabbit heart. It is believed that the nature of the antagonism between ephedrine and cocaine is noncompetitive, e. g., the two drugs combine with different parts of the receptor mechanism.
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This paper concerns the least-energy solutions to a semilinear elliptic equation. The role of geometry of the boundary is studied when a parameter in the boundary condition tends to a critical index as well as to inlinity. . 1995 Acadernic Press. Inc.
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Axolotl females homozygous for __o__ produce eggs which are fertilizable and cleave normally, but are invariably arrested during gastrulation. This block can be corrected by injecting the eggs with nuclear sap from normal (__o__^+^/__o__^+^ or __o__^+^/__o__) ovarian oocytes. The factor