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Further studies on the biosynthesis of the non-tryptophan derived portion of ajmaline and related alkaloids

✍ Scribed by Edward Leete; Shibnath Ghosal

Publisher
Elsevier Science
Year
1962
Tongue
French
Weight
215 KB
Volume
3
Category
Article
ISSN
0040-4039

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✦ Synopsis

IN a recent communication' we reported that the administration of sodium acetate-l-Cl4 to Bauuolfia serpentina plants led to the formation of radioactive ajmaline (III) which had one half of its total activity located at C3 and C19. This result is consistent with the biogenetic scheme illustrated in Fig. 1. The poly-&-keto ester (I) is formed from three molecules of acetylcoenayme A. A one carbon side chain derived from formaldehyde, or its biological equivalent, is introduced at C3. Feeding experiments with sodium formate-C 14 substantiate this idea2. At C4

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