Further studies of the selective inhibition by ouabain of antigen-induced proliferation of human lymphocytes
β Scribed by Pamela Weight; J.G. Kaplan
- Book ID
- 115810883
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- English
- Weight
- 671 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0008-8749
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Ouabain, a specific inhibitor of the Na-K ATPase, has been shown to exert immunosuppressive effects. The goals of this study were to define the stage of the proliferative response which is sensitive to ouabain and to correlate the inhibitory action of ouabain on cell proliferation with its effect on
## Abstract In the course of a study of lymphocyte responses to microbial antigens in HIVβinfected patients, we detected a previously unrecognized phenomenon of inhibition of lymphocyte baseline proliferation, induced by the presence of tetanus toxoid and __Escherichia coli__ in the cultures. The e
## Abstract Mitogenesis of human blood lymphocytes in culture is inhibited by concentrations of ouabain that are approximately one order of magnitude lower than those that block Na and K transport. For example, the 50% inhibition (ID~50~) of NaβK transport, 280 nM, is sevenβfold greater than the ID