Oxidations of dopamine (DA), norepinephrine (NE), and epinephrine (EPI) at pH 7.4 in the presence of free L-cysteine (CySH) have been previously shown to generate a number of cysteinyl conjugates of these catecholaminergic neurotransmitters that serve as precursors of various dihydrobenzothiazines (
Further insights into the oxidation chemistry of 5-hydroxytryptamine
β Scribed by Monika Z. Wrona; Glenn Dryhurst
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 719 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0022-3549
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The oxidation chemistry of the chemical neurotransmitter dopamine (DA) has been investigated using electrochemical approaches. At physiological \(\mathrm{pH}\) in aqueous solution DA is initially oxidized at a pyrolytic graphite electrode in a reversible \(2 e, 2 \mathrm{H}^{+}\)reaction to give DA-
The p-fluoro labeling technique is used to demonstrate that the ions formed by the loss of CO from tetracyclones pass through a tetrahedral transition state or intermediate before they fragment. ISOTOPIC labeling techniques have a well established place in the determination of reaction mechanisms i