Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin
โ Scribed by Theo B. A. Mulder; Jan B. Vries; Durk Dijkstra; Johann W. Wiechers; Cor J. Grol; Alan S. Horn
- Book ID
- 112275600
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 1018 KB
- Volume
- 336
- Category
- Article
- ISSN
- 0028-1298
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The in vitro autoradiographic binding characteristics as well as in vivo imaging characteristics of a dopamine D2 receptor agonist, (R,S)-2-(N-propyl-N-1ะ-11 Cpropyl)amino-5-hydroxytetralin ( 11 C-5-OH-DPAT), were studied. In 3 H-spiperone assays using rat striata, 5-OH-DPAT exhibited an affinity of