## Background: Signal hyperintensities on magnetic resonance imaging in late-life depression are associated with treatment resistance and poor outcome. these lesions are probably vascular in origin and proposed sites for vascular damage include the dorsolateral prefrontal cortex (dlpfc) and anterio
Further evidence of attention bias for negative information in late life depression
β Scribed by Niall M. Broomfield; Rachel Davies; Kenneth MacMahon; Farah Ali; Susan M. B. Cross
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 96 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0885-6230
- DOI
- 10.1002/gps.1655
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β¦ Synopsis
Abstract
Objectives
Pilot research using the manual (card based) emotional Stroop paradigm shows depressed elders selectively attend negative words, whereas dementia patients do not. The present study aimed to confirm this effect, using a more controlled, computerised, emotional Stroop paradigm, and accounting for coβmorbid anxiety.
Method
Nineteen depressed (DEP) and twenty non depressed control participants (CON) completed a computerised Emotional Stroop task. This task involves colour naming individually presented negative, positive and neutral words. Mean participant age was 72.25 years. All participants were free of significant cognitive impairment.
Results
Consistent with hypotheses, analysis of variance revealed a general cognitive slowing amongst DEP, and a specific interference effect for negative words, in this group, suggesting attention bias.
Conclusions
Previous pilot data are confirmed. The emotional Stroop paradigm may have clinical potential for distinguishing geriatric depression and dementia, although as yet this is far from clear. Detailed development work including comparison with depressed and non depressed Alzheimer's patients, will be necessary to demonstrate diagnostic validity. Copyright Β© 2006 John Wiley & Sons, Ltd.
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