Further Evidence for the Critical Role of a Non-Chair Conformation of L-Iduronic Acid in the Activation of Antithrombin

Synthesis of Conformationally Locked l-I

Synthesis of Conformationally Locked l-Iduronic Acid Derivatives: Direct Evidence for a Critical Role of the Skew-Boat 2S0 Conformer in the Activation of Antithrombin by Heparin

✍ Sanjoy K. Das; Jean-Maurice Mallet; Jacques Esnault; Pierre-Alexandre Driguez; P 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 298 KB 👁 1 views

We have used organic synthesis to understand the role of liduronic acid conformational flexibility in the activation of antithrombin by heparin. Among known synthetic analogues of the genuine pentasaccharidic sequence representing the antithrombin binding site of heparin, we have selected as a refer