Further evaluation of immunocytochemical staining in the diagnosis of early myocardial ischaemic/hypoxic damage

✍ Scribed by Stephen Leadbeatter; Helen M. Wawman; Bharat Jasani

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 407 KB
• Volume: 45
• Category: Article
• ISSN: 0379-0738
• DOI: 10.1016/0379-0738(90)90230-v

✦ Synopsis

The pattern of immunocytochemical staining with antibodies to caeruloplasmin, myosin, myoglobin and C-reactive protein seen in myocardium taken from deaths with macroscopic evidence of myocardial infarction and/or significant coronary artery atherosclerosis and from deaths with neither of these lesions has been correlated with H&E, PTAH and HBFP staining of myocardium and circumstances of each death indicative of antemortem hypoxia and/or ischaemia. Loss of staining with these antibodies correlated well with fuchsinorrhagia and both techniques are more sensitive than H&E and PTAH staining in the detection of early ischaemic/hypoxic damage to myocardium. However, their sensitivity is such that they appear to detect agonal changes and, therefore, cannot be used for specific diagnosis of early myocardial infarction.